Mechanical stimulation enhances endothelin-1 hyperalgesia
نویسندگان
چکیده
منابع مشابه
Cerebral Activation during Von Frey Filament Stimulation in Subjects with Endothelin-1-Induced Mechanical Hyperalgesia: A Functional MRI Study
Endothelin-1 (ET-1) is an endogenously expressed potent peptide vasoconstrictor. There is growing evidence that ET-1 plays a role in the pain signaling system and triggers overt nociception in humans. The underlying neuronal pathways are still a matter of great debate. In the present study, we applied an intradermal ET-1 sensitization model to induce mechanical hyperalgesia in healthy subjects....
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Endothelin-1 (ET-1) is unique among a broad range of hyperalgesic agents in that it induces hyperalgesia in rats that is markedly enhanced by repeated mechanical stimulation at the site of administration. Antagonists to the ET-1 receptors, ET(A) and ET(B), attenuated both initial as well as stimulation-induced enhancement of hyperalgesia (SIEH) by endothelin. However, administering antisense ol...
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Cancer pain is often difficult to treat. Growing evidence indicates that chemical mediators secreted by the tumor itself play an important role in the development of cancer pain. One such mediator, endothelin-1 (ET-1) is secreted by different tumor types. Studies have indicated that ET-1 induces spontaneous and evoked nociception in rodents and in humans. The focus of all these studies has alwa...
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*Corresponding author: 12 Emanuel N van den Broeke 13 Institute of Neuroscience (IoNS) 14 Faculty of Medicine 15 Université catholique de Louvain 16 B-1200, Brussels 17 Belgium 18 E-mail: [email protected] 19 20 21 Running Head: HFS and hyperalgesia 22 23
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ژورنال
عنوان ژورنال: Neuroscience
سال: 2011
ISSN: 0306-4522
DOI: 10.1016/j.neuroscience.2011.01.043